Melissa McCarthy

Detective Connie Edwards

Bill Barretta

Phil Philips / Junkyard / Boar (voice)

Leslie David Baker

Lt. Banning

Elizabeth Banks

Jenny

Joel McHale

Agent Campbell

Maya Rudolph

Bubbles

Dorien Davies

Sandra (voice)

Drew Massey

Goofer / Vinny (voice)

Kevin Clash

Bumblypants / Lyle (voice)

Michael McDonald

Ronovan Scargle

Cynthy Wu

Brittenie Marlowe

Mitch Silpa

Tommy

Hemky Madera

Tito

Benjamin Royer

Rick

Brekkan Spens

Dick

Ryan Tran

Phil

Fortune Feimster

Robin

Brian Palermo

Paramedic

Damon Jones

Police Station Guard John / Puppet Doctor (voice)

Ryan Gaul

Officer Milligan

Jimmy O. Yang

Officer Delancey

Dennis Keiffer

Junior

Jim Palmer

Caesar

H. Michael Croner

Jack Cook

Barry Rothbart

Fireman

Steve Mallory

Kerry

Dana Schick

Pretty Girl

Jaye Razor

Razor

Jen Sung

Sandra's Bodyguard

Bryan Cartago

Sandra's Bodyguard

Brett Wagner

Rio

Colleen Smith

Carol / Dalmatian / Cara (voice)

Ben Falcone

Donny

Victor Yerrid

Larry / Old Man Puppet (voice)

Ted Michaels

Sexist Thug / Ezra (voice)

Brian Henson

Crab

Patty Guggenheim

Roxy

Donna Kimball

Roxy / Cow / Rotten Cotton Girl (voice)

Alice Dinnean

Rotten Cotton Girl (voice)

Allan Trautman

Octopus / Puppet Doctor (voice)