John Wayne

Col. Cord McNally

Jorge Rivero

Capt. Pierre Cordona

Jennifer O'Neill

Shasta Delaney

Jack Elam

Phillips

Christopher Mitchum

Sgt. Tuscarora Phillips

Victor French

Ketcham

Susana Dosamantes

Maria Carmen

Sherry Lansing

Amelita

David Huddleston

Dr. Ivor Jones

Mike Henry

Rio Lobo Sheriff 'Blue Tom' Hendricks

Bill Williams

Blackthorne Sheriff Pat Cronin

Jim Davis

Riley

Dean Smith

Bide

Robert Donner

Whitey Carter

George Plimpton

George, Whitey's 4th Henchman

Edward Faulkner

Lt. Harris

Peter Jason

Lt. Ned Forsythe

Chuck Courtney

Chuck, Whitey's 2nd Henchman

Robert Rothwell

Whitey's 3rd Henchman

Don 'Red' Barry

Feeny - Bartender (uncredited)

Sondra Currie

Blackthorne Prostitute (uncredited)

Chuck Hayward

(uncredited)

Conrad Hool

Bart (uncredited)

Lance Hool

Picket (uncredited)

John Hudkins

Rio Lobo Deputy (uncredited)

Michael Jeffers

Barfly in Blackthorne (uncredited)

Frank Kennedy

Minor Role (uncredited)

Richard LaMarr

Man in Army Post Saloon (uncredited)

John McKee

Rio Lobo Deputy (uncredited)

Boyd 'Red' Morgan

Train Engineer (uncredited)

William H. O'Brien

Man in Army Post Saloon (uncredited)

Gregg Palmer

Pete - Henchman (uncredited)

Jim Prejean

Union Soldier (uncredited)

Rudy Robbins

Man (uncredited)

Chuck Roberson

Corporal in Baggage Car (uncredited)

Danny Sands

Man Delivering Message to Jail (uncredited)

Cap Somers

Card Player (uncredited)

Bob Steele

Rio Lobo Deputy (uncredited)

Tommy Tedesco

Guitar Player in Opening Credits (uncredited)

Ethan Wayne

Boy (uncredited)

Hank Worden

Hank - Hotel Clerk (uncredited)