Dennis Quaid

Lt. Tuck Pendleton

Martin Short

Jack Putter

Meg Ryan

Lydia Maxwell

Kevin McCarthy

Victor Eugene Scrimshaw

Fiona Lewis

Dr. Margaret Canker

Vernon Wells

Mr. Igoe

Robert Picardo

The Cowboy

Wendy Schaal

Wendy

Harold Sylvester

Pete Blanchard

William Schallert

Dr. Greenbush

Henry Gibson

Mr. Wormwood

John Hora

Ozzie Wexler

Mark L. Taylor

Dr. Niles

Orson Bean

Lydia's Editor

Kevin Hooks

Duane

Kathleen Freeman

Dream Lady

Archie Hahn

Messenger

Dick Miller

Cab Driver

Kenneth Tobey

Man in Restroom

Joe Flaherty

Waiting Room Patient

Andrea Martin

Waiting Room Patient

Jason Laskay

Scrimshaw's Henchman

Frank Miller

Scrimshaw's Henchman

Shawn Nelson

Wendell

Christine Avila

Lab Technician

Alexandra Borrie

Lab Technician

Jenny Gago

Lab Technician

Robert Gounley

Lab Technician

Grainger Hines

Rusty

Mike Garibaldi

Cop

Richard McGonagle

Cop

Terence McGovern

Travel Agent

Robert Neches

Lab Guard

Rance Howard

Supermarket Customer

Chuck Jones

Supermarket Customer

Laura Waterbury

Supermarket Customer

Kurt Braunreiter

Lab Assault Henchman

Robert Gray

Lab Assault Henchman

Brewster Sears

Lab Assault Henchman

Alan Blumenfeld

Man with Camera

Jeffrey Boam

Lydia's Interviewee

Sydne Squire

Stewardess

Paul Barselou

Man on Plane

John Miranda

Man in Elevator

Jordan Benjamin

Little Kid in Mall

Roberto Ramirez

Chef

Virginia Boyle

Shopping Lady

Herb Mitchell

Camera Store Clerk

John Harwood

Lab Henchman

Neil Ross

Pod Computer (voice)

Charles Aidman

Speaker at Banquet

Joe Dante

Vectorscope Employee (uncredited)